Szerzők:
Molnár Mónika
Nyíregyházi Egyetem
Cím: PATOGÉN ÉLESZTŐK
DOI: https://doi.org/10.71066/AANY.2026.13.18
Megjelent:
Összefoglaló
ÖSSZEFOGLALÓ
A patogén gombák által okozott megbetegedések komoly terhet jelentenek az egészségügynek világszerte. Az embert megbetegíteni képes gombafajok legnagyobb része élesztőgomba. Közülük is kiemelkedő jelentőségű az opportunista patogén Candida albicans, amely a legtöbb fertőzést előidéző humánpatogén faj. Ez az áttekintés röviden tárgyalja a legjelentősebb patogén élesztők jellemzőit, majd összefoglalja a C. albicans legfontosabb sajátságait. Végül a C. albicans biológiájának néhány lényeges s egyben legérdekesebbnek talált területét érintem, amelyek: a fonalas növekedésre váltás és a patogenitás összefüggése, a faj paraszexuális ciklusa, valamint a Candida biofilmek sajátságai.
Kulcsszavak: patogén élesztők, Candida albicans, fonalas növekedés, paraszexuális ciklus, biofilm
ABSTRACT Diseases caused by fungal pathogens place a heavy burden on healthcare worldwide. The majority of fungal pathogen species are yeasts. Among them, the opportunistic pathogen Candida albicans is of outstanding importance, being the most common cause of human infections. This review briefly discusses the characteristics of the most important pathogenic yeasts, followed by a summary of the typical features of C. albicans. Finally, I touch on some important and at the same time most interesting areas of the biology of C. albicans, such as the correlation between filamentous growth and pathogenicity, the parasexual cycle of the species, and the characteristics of Candida biofilms.
Keywords: yeast pathogens, Candida albicans, filamentous growth, parasexual cycle, biofilm
FELHASZNÁLT SZAKIRODALOM
Arai, T.–Mikami, Y.–Yokoyama, K. (1977): Phagocytosis of Candida albicans by rabbit alveolar macrophages and guinea pig neutrophils. Sabouraudia 15: 171–7. https://doi.org/10.1080/00362177785190261
Barnett, J. A. (2008): A history of research on yeasts 12: medical yeasts, part 1, Candida albicans. Yeast 25: 385-417. https://doi.org/10.1002/yea.1595Bedekovic, T.–Usher, J. (2023): Is there a relationship between mating and pathogenesis in two human fungal pathogens, Candida albicans and Candida glabrata? Curr Clin Microbiol Rep 10: 47–54. https://doi.org/10.1007/s40588-023-00192-8
Bennet, R. J.–Johnson, A. D. (2003): Completion of a parasexual cycle in Candida albicans by induced chromosome loss in tetraploid strains. EMBO J 22: 2505–15. https://doi.org/10.1093/emboj/cdg235
Bruns, T. (2006): Evolutionary biology: a kingdom revised. Nature 443: 758–61. https://doi.org/10.1038/443758a
Casadevall, A.–Kontoyiannis, D. P.–Robert, V. (2021): Environmental Candida auris and the global warming emergence hypothesis. mBio 12: e00360-21. https://doi.org/10.1128/mBio.00360-21
Drell, T.–Lillsaar, T.–Tummeleht, L.–Simm, J.–Aaspõllu, A.–Väin, E.–Saarma, I.–Salumets, A.–Donders, G. G. G.–Metsis, M. (2013): Characterization of the vaginal micro- and mycobiom in asymptomatic reproductive-age Estonian women. PLoS One 8: e54379. https://doi.org/10.1371/journal.pone.0054379
Forche, A.–Alby, K.–Schaefer, D.–Johnson, A. D.–Berman, J.–Bennett, R. J. (2008): The parasexual cycle in Candida albicans provides an alternative pathway to meiosis for the formation of recombinant strains. PLoS Biol 6: e110. https://doi.org/10.1371/journal.pbio.0060110
Freij, J. B.–Freij, B. J. (2015): The earliest account of human Cryptococcosis (Busse- Buschke disease) in a woman with chronic osteomyelitis of the tibia. Pediatr Infect Dis J 34: 1278. https://doi.org/10.1097/INF.0000000000000865
Gebhardt, L. P.–Hill, D. W. (1956): Morphological transformation of Candida albicans in tissues of mice. Proc Soc Exp Biol Med 92: 640–4. https://doi.org/10.3181/00379727-92-22570
Ghannoum, M. A.–Jurevic, R. J.–Mukherjee, P. K.–Cui, F.–Sikaroodi, M.–Naqvi, A.–Gillevet, P. M. (2010): Characterization of the oral fungal microbiom (mycobiom) in healthy individuals. PLoS Pathog 6: e1000713. https://doi.org/10.1371/journal.ppat.1000713
Gimeno, C. J.–Ljungdahl, P. O.–Styles, C. A.–Fink, G. R. (1992): Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS. Cell 68: 1077–90. https://doi.org/10.1016/0092-8674(92)90079-R
Hawser, S. P.–Douglas, L. J. (1994): Biofilm formation by Candida species on the surface of catheter materials in vitro. Infect Immun 62: 915–21. https://doi.org/10.1128/iai.62.3.915-921.1994
Hawser, S. P.–Douglas, L. J. (1995): Resistance of Candida albicans biofilms to antifungal agents in vitro. Antimicrob Agents Chemother 39: 2128–31. https://doi.org/10.1128/AAC.39.9.2128
Hilton, C.–Markie, D.–Corner, B.–Rikkerink, E.–Poulter, R. (1985): Heat shock induces chromosome loss in the yeast Candida albicans. Mol Gen Genet 200: 162–168. https://doi.org/10.1007/BF00383330
Hoffmann, C.–Dollive, S.–Grunberg, S.–Chen, J.–Li, H.–Wu, G. D.–Lewis, J. D.–Bushman,
F. D. (2013): Archaea and fungi of the human gut microbiom: correlation with diet and bacterial residents. PloS One 8: e66019. https://doi.org/10.1371/journal.pone.0066019
Hull, C. M.–Johnson, A. D. (1999): Identification of a mating type-like locus in the asexual pathogenic yeast Candida albicans. Science 285: 1271–5. https://doi.org/10.1126/science.285.5431.1271
Hull, C. M.–Raisner, R. M.–Johnson, A. D. (2000): Evidence for mating of the ″asexual" yeast
Candida albicans in a mammalian host. Science 289: 307–10. https://doi.org/10.1126/science.289.5477.307Jones, T.–Federspiel, N. A.–Chibana, H. et al. (2004): The diploid genome sequence of Candida albicans. Proc Natl Acad Sci USA 101: 7329–34.
https://doi.org/10.1073/pnas.0401648101
Kabir, M. A.–Hussain, M. A.–Ahmad, Z. (2012): Candida albicans: a model organism for
studying fungal pathogens. ISRN Microbiol 2012: 538694.
https://doi.org/10.5402/2012/538694
Kaur, J.–Nobile, C. J. (2023): Antifungal drug-resistance mechanisms in Cadida biofilms. Curr
Opin Microbiol 71: 102237. https://doi.org/10.1016/j.mib.2022.102237
Köhler, J. R.–Casadevall, A.–Perfect, J. (2014): The spectrum of fungi that infects humans.
Cold Spring Harb Perspect Med 5: a019273. https://doi.org/10.1101/cshperspect.a019273
Lasker, B. A.–Carle, G. F.–Kobayashi, G. S.–Medoff, G. (1989): Comparison of the separation of Candida albicans chromosome-sized DNA by pulsed-field electrophoresis techniques. Nucleic Acids Res 17: 3783-93. https://doi.org/10.1093/nar/17.10.3783
Liu, H.–Köhler, J.–Fink, G. R. (1994): Suppression of hyphal formation in Candida albicans
by mutation of a STE12 homolog. Science 266: 1723-6. https://doi.org/10.1126/science.7992058
Lo, H. J.–Köhler, J. R.–DiDomenico, B.–Loebenberg, D.–Cacciapuoti, A.–Fink, G. R. (1997):
Nonfilamentous C. albicans mutants are avirulent. Cell 90: 939–49.
https://doi.org/10.1016/S0092-8674(00)80358-X
Lockhart, S. R.–Etienne, K. A.–Vallabhaneni, S. et al. (2017): Simultaneous emergence of
multidrug-resistant Candida auris on 3 continents confirmed by whole-genome sequencing
and epidemiological analyses. Clin Infect Dis 64: 134–140.
https://doi.org/10.1093/cid/ciw691
Lohse, M. B.–Gulati, M.–Johnson, A. D.–Nobile, C. J. (2018): Development and regulation
of single- and multi-species Candida albicans biofilms. Nat Rev Microbiol 16: 19–31.
https://doi.org/10.1038/nrmicro.2017.107
Magee, B. B.–Magee, P. T. (2000): Induction of mating in Candida albicans by construction
of MTLa and MTLalpha strains. Science 289: 310–3. https://doi.org/10.1126/science.289.5477.310
Mayer, F. L.–Wilson, D.–Hube, B. (2013): Candida albicans pathogenicity mechanisms. Virulence 4: 119-28. https://doi.org/10.4161/viru.22913
Miller, M. G.–Johnson, A. D. (2002): White-opaque switching in Candida albicans is controlled by mating-type locus homeodomain proteins and allows efficient mating. Cell 110:
293–302. https://doi.org/10.1016/S0092-8674(02)00837-1
Molnár, M. (2022): Élesztőgombák régóta ismert és újonnan felfedezett élőhelyeken. Acta
Academiae Nyiregyhaziensis 6: 349–362.
Noble, S. M.–Gianetti, B. A.–Witchley, J. N. (2017): Candida albicans cell-type switching
and functional plasticity in the mammalian host. Nat Rev Microbiol 15: 96–108.
https://doi.org/10.1038/nrmicro.2016.157
Odds, F. C. (1985): Morphogenesis in Candida albicans. Crit Rev Microbiol 12: 45–93.
https://doi.org/10.3109/10408418509104425
Olaiya, A. F.–Sogin, S. J. (1979): Ploidy determination in Candida albicans. J Bacteriol 140:
1043-9. https://doi.org/10.1128/jb.140.3.1043-1049.1979
Pande, K.–Chen, C.–Noble, S. M. (2013): Passage through the mammalian gut triggers a pheotypic switch that promotes Candida albicans commensalism. Nat Genet 45: 1088–91.
https://doi.org/10.1038/ng.2710
Park, Y-N.–Daniels, K. J.–Pujol, C.–Srikantha, Y.–Soll, D. R. (2013): Candida albicans forms
a specialized ″sexual" as well as ″pathogenic" biofilm. Eukaryot Cell 12: 1120–31.
https://doi.org/10.1128/EC.00112-13
Poulter, R.–Jeffery, K.–Hubbard, M. J.–Shepherd, M. G.–Sullivan, P. A. (1981): Parasexual
genetic analysis of Candida albicans by spheroplast fusion. J Bacteriol 146: 833–40.
https://doi.org/10.1128/jb.146.3.833-840.1981
Rhodes, J.–Fischer, M. C. (2019): Global epidemiology of emerging Candida auris. Curr Opin
Microbiol 52: 84–89. https://doi.org/10.1016/j.mib.2019.05.008
Rokas, A. (2022): Evolution of the human pathogenic lifestyle in fungi. Nat Microbiol 7: 607–
619. https://doi.org/10.1038/s41564-022-01112-0
Satoh, K.–Makimura, K.–Hasumi, Y.–Nishiyama, Y.–Uchida, K.–Yamaguchi, Y. (2009):
Candida auris sp. nov., a novel ascomycetous yeast isolated from the external ear canal of
an inpatient in a Japanese hospital. Microbiol Immunol 53: 41–4.
https://doi.org/10.1111/j.1348-0421.2008.00083.x
Slutsky, B.–Buffo, J.–Soll, D. R. (1985): High-frequency switching of colony morphology in
Candida albicans. Science 230: 666–9. https://doi.org/10.1126/science.3901258
Slutsky, B.–Staebell, M.–Anderson, J.–Risen, L.–Pfaller, M.–Soll, D. R. (1987): ″Whiteopaque transition": a second high-frequency switching system in Candida albicans. J Bacteriol 169: 189–97. https://doi.org/10.1128/jb.169.1.189-197.1987
Sudbery, P. E. (2011): Growth of Candida albicans hyphae. Nat Rev Microbiol 9: 737–48.
https://doi.org/10.1038/nrmicro2636
Sudbery, P.–Gow, N.–Berman, J. (2004): The distinct morphogenetic states of Candida albicans. Trends Microbiol 12: 317–24. https://doi.org/10.1016/j.tim.2004.05.008
Staib, P.–Morschhäuser, J. (2007): Chlamydospore formation in Candida albicans and Candida dubliniensis – an enigmatic developmental programme. Mycoses 50: 1–12.
https://doi.org/10.1111/j.1439-0507.2006.01308.x
Stoldt, V. R.–Sonneborn, A.–Leuker, C. E.–Ernst, J. F. (1997): Efg1p, an essential regulator
of morphogenesis of the human pathogen Cadida albicans, is a member of a conserved
class of bHLH proteins regulating morphogenetic processes in fungi. EMBO J 16: 1982–
91. https://doi.org/10.1093/emboj/16.8.1982
Tchekmedyian, N. S.–Newman, K.–Moody, M. R.–Costerton, J. W.–Aisner, J.–Schimpff, S.
C.–Reed, W. P. (1986): Special studies of the Hickman catheter of a patient with recurrent
bacteremia and candidemia. Am J Med Sci 291: 419–24.
https://doi.org/10.1097/00000441-198606000-00009
Yi, S.–Sahni, N.–Daniels, K. J.–Lu, K. L.–Srikantha, T.–Huang, G.–Garnaas, A. M.–Soll D.
R. (2011): Alternative mating type configurations (a/α versus a/a or α/α) of Candida albicans result in alternative biofilms regulated by different pathways. PLoS Biol 9: e1001117.
https://doi.org/10.1371/journal.pbio.1001117
Young, G. (1958): The process of invasion and the persistence of Candida albicans injected
intraperitoneally into mice. J Infect Dis 102: 114–20.
https://doi.org/10.1093/infdis/102.2.114
Zhao, Y.–Ye, L.–Zhao, F., et al. (2023): Cryptococcus neoformans, a global threat to human
health. Infect Dis Poverty 12: 20. https://doi.org/10.1186/s40249-023-01073-4
Internet 1. https://www.who.int/publications/i/item/9789240060241)
Honlap: https://www.who.int/publications/i/item/9789240060241